LymphedemaV1, Main, Exploration, bibRecord, 004C55

Physical and Psychosocial Recovery in the Year After Primary Treatment of Breast Cancer

Identifieur interne : 004C55 ( Main/Exploration ); précédent : 004C54; suivant : 004C56

Physical and Psychosocial Recovery in the Year After Primary Treatment of Breast Cancer

Auteurs : Patricia A. Ganz ; Lorna Kwan ; Annette L. Stanton ; Julienne E. Bower ; Thomas R. Belin

Source :

Journal of Clinical Oncology [ 0732-183X ] ; 2011.

RBID : PMC:3083865

Abstract

Purpose

The 2000 National Institutes of Health Consensus Conference on Adjuvant Therapy of Breast Cancer recommended chemotherapy for all women with invasive cancer greater than 1 centimeter. Studies of long-term breast cancer survivors have found poorer quality of life (QOL) in women who received adjuvant chemotherapy. The aim of this article is to characterize physical and psychosocial recovery as a function of chemotherapy receipt in the year after medical treatment completion.

Patients and Methods

Prospective longitudinal survey data (RAND SF-36 and Breast Cancer Prevention Trial [BCPT] Symptom Scales) collected from 558 women with breast cancer enrolled on the Moving Beyond Cancer (MBC) psychoeducational intervention trial were compared according to receipt of chemotherapy. MBC study enrollment occurred within 4 weeks after the end of primary treatment (eg, surgery, chemotherapy, radiation). Self-report questionnaire data collected at enrollment and at 2, 6, and 12 months thereafter were examined, controlling for intervention and with propensity score adjustment for imbalance of covariates. Outcome analyses were carried out by fitting linear mixed models by using SAS PROC MIXED.

Results

Longitudinal SF-36 scale scores did not differ by chemotherapy treatment exposure, and both groups improved significantly (P < .01) in the year after primary treatment ended. However, adjuvant chemotherapy treatment was associated with significantly more severe physical symptoms, including musculoskeletal pain (P = .01), vaginal problems (P < .01), weight problems (P = .01), and nausea (P = .03).

Conclusion

Physical and psychosocial functioning improved significantly after breast cancer treatment, independent of receipt of adjuvant chemotherapy. Women who received chemotherapy experienced more severe and persistent physical symptoms that should be more effectively managed as part of survivorship care.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083865

DOI: 10.1200/JCO.2010.28.8043
PubMed: 21300931
PubMed Central: 3083865

Affiliations:

Le document en format XML

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<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
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<author><name sortKey="Kwan, Lorna" sort="Kwan, Lorna" uniqKey="Kwan L" first="Lorna" last="Kwan">Lorna Kwan</name>
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<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
<affiliation><nlm:aff id="aff1">From the School of Public Health; Jonsson Comprehensive Cancer Center; David Geffen School of Medicine; and Cousins Center for Psychoneuroimmunology; Semel Institute, University of California, Los Angeles, CA.</nlm:aff>
<wicri:noCountry code="subfield">CA.</wicri:noCountry>
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<author><name sortKey="Kwan, Lorna" sort="Kwan, Lorna" uniqKey="Kwan L" first="Lorna" last="Kwan">Lorna Kwan</name>
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<wicri:noCountry code="subfield">CA.</wicri:noCountry>
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<author><name sortKey="Stanton, Annette L" sort="Stanton, Annette L" uniqKey="Stanton A" first="Annette L." last="Stanton">Annette L. Stanton</name>
<affiliation><nlm:aff id="aff1">From the School of Public Health; Jonsson Comprehensive Cancer Center; David Geffen School of Medicine; and Cousins Center for Psychoneuroimmunology; Semel Institute, University of California, Los Angeles, CA.</nlm:aff>
<wicri:noCountry code="subfield">CA.</wicri:noCountry>
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<author><name sortKey="Bower, Julienne E" sort="Bower, Julienne E" uniqKey="Bower J" first="Julienne E." last="Bower">Julienne E. Bower</name>
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<series><title level="j">Journal of Clinical Oncology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>The 2000 National Institutes of Health Consensus Conference on Adjuvant Therapy of Breast Cancer recommended chemotherapy for all women with invasive cancer greater than 1 centimeter. Studies of long-term breast cancer survivors have found poorer quality of life (QOL) in women who received adjuvant chemotherapy. The aim of this article is to characterize physical and psychosocial recovery as a function of chemotherapy receipt in the year after medical treatment completion.</p>
</sec>
<sec><title>Patients and Methods</title>
<p>Prospective longitudinal survey data (RAND SF-36 and Breast Cancer Prevention Trial [BCPT] Symptom Scales) collected from 558 women with breast cancer enrolled on the Moving Beyond Cancer (MBC) psychoeducational intervention trial were compared according to receipt of chemotherapy. MBC study enrollment occurred within 4 weeks after the end of primary treatment (eg, surgery, chemotherapy, radiation). Self-report questionnaire data collected at enrollment and at 2, 6, and 12 months thereafter were examined, controlling for intervention and with propensity score adjustment for imbalance of covariates. Outcome analyses were carried out by fitting linear mixed models by using SAS PROC MIXED.</p>
</sec>
<sec><title>Results</title>
<p>Longitudinal SF-36 scale scores did not differ by chemotherapy treatment exposure, and both groups improved significantly (<italic>P</italic>
 < .01) in the year after primary treatment ended. However, adjuvant chemotherapy treatment was associated with significantly more severe physical symptoms, including musculoskeletal pain (<italic>P</italic>
 = .01), vaginal problems (<italic>P</italic>
 < .01), weight problems (<italic>P</italic>
 = .01), and nausea (<italic>P</italic>
 = .03).</p>
</sec>
<sec><title>Conclusion</title>
<p>Physical and psychosocial functioning improved significantly after breast cancer treatment, independent of receipt of adjuvant chemotherapy. Women who received chemotherapy experienced more severe and persistent physical symptoms that should be more effectively managed as part of survivorship care.</p>
</sec>
</div>
</front>
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<tree><noCountry><name sortKey="Belin, Thomas R" sort="Belin, Thomas R" uniqKey="Belin T" first="Thomas R." last="Belin">Thomas R. Belin</name>
<name sortKey="Bower, Julienne E" sort="Bower, Julienne E" uniqKey="Bower J" first="Julienne E." last="Bower">Julienne E. Bower</name>
<name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
<name sortKey="Kwan, Lorna" sort="Kwan, Lorna" uniqKey="Kwan L" first="Lorna" last="Kwan">Lorna Kwan</name>
<name sortKey="Stanton, Annette L" sort="Stanton, Annette L" uniqKey="Stanton A" first="Annette L." last="Stanton">Annette L. Stanton</name>
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Physical and Psychosocial Recovery in the Year After Primary Treatment of Breast Cancer

Physical and Psychosocial Recovery in the Year After Primary Treatment of Breast Cancer

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